Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis

Psoriasis and Atopic Dermatitis

Psoriasis and atopic dermatitis are common, chronic inflammatory skin diseases. We discuss several aspects of these disorders, including: risk factors; incidence and prevalence; the complex disease burden; and the comorbidities that increase the clinical significance of each disorder. We also focus on treatment management strategies and outline why individualized, patient-centered treatment reg...

Aryl hydrocarbon receptor activation restores filaggrin expression via OVOL1 in atopic dermatitis

Filaggrin (FLG) mutation is a well-confirmed genetic aberration in atopic dermatitis (AD). Genome-wide association studies on AD have revealed other susceptibility genes, for example, Ovo-like 1 (OVOL1). Nonetheless, the relation between FLG and OVOL1 is unclear. Because aryl hydrocarbon receptor (AHR; a ligand-activated transcription factor), plays a role in FLG expression in keratinocytes, we...

Coexistence of psoriasis and atopic dermatitis

Psoriasis is a recurrent inflammatory skin disease which affects around 2% of the population and is characterized by erythematous papules and plaques covered with silvery white scales. [1]. Atopic dermatitis (AD) is a common skin condition, particularly in children, regarded as one of the 50 most prevalent diseases worldwide [2]. Prevalence of AD in adult patients is around 1-3 % [3]. Patients ...

Aryl Hydrocarbon Receptor Activation

TWEAK mediates inflammation in experimental atopic dermatitis and psoriasis

Atopic dermatitis (AD) and psoriasis are driven by alternate type 2 and type 17 immune responses, but some proteins might be critical to both diseases. Here we show that a deficiency of the TNF superfamily molecule TWEAK (TNFSF12) in mice results in defective maintenance of AD-specific T helper type 2 (Th2) and psoriasis-specific Th17 cells in the skin, and impaired expression of disease-charac...